VacA pores as portable portals for urea.
نویسنده
چکیده
منابع مشابه
The Helicobacter pylori VacA toxin is a urea permease that promotes urea diffusion across epithelia.
Urease and the cytotoxin VacA are two major virulence factors of the human pathogen Helicobacter pylori, which is responsible for severe gastroduodenal diseases. Diffusion of urea, the substrate of urease, into the stomach is critically required for the survival of infecting H. pylori. We now show that VacA increases the transepithelial flux of urea across model epithelia by inducing an unsatur...
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عنوان ژورنال:
- The Journal of clinical investigation
دوره 108 6 شماره
صفحات -
تاریخ انتشار 2001